Influencing factors for the development of obstructive sleep apnea after orthognathic surgery in skeletal class III patients: A systematic review.

This systematic review aimed to investigate the factors that may contribute to the development of OSA after orthognathic surgery in patients with skeletal class III. Electronic searches of PubMed, Embase, Web of Science, and Cochrane databases were conducted up to December 10, 2022. In total, 277 studies were retrieved and screened according to the inclusion and exclusion criteria, and 14 were finally selected. All studies were of medium quality (moderate risk of bias). The occurrence of OSA after orthognathic surgery in patients with class III skeletal relationships depends on surgical factors and patient self-factors. Surgical factors include surgery type, amount of maxillary and mandibular movement, and the patient's postoperative swelling. Patient self-factors include weight, age, gender, and hypertrophy of the soft palate, tonsils, and tongue. According to information in the 14 selected articles, the incidences of OSA after Le Fort I impaction and BSSO setback, BSSO setback, and Le Fort I advancement and BSSO setback were 19.2%, 8.57%, and 0.7%, respectively, mostly accompanied with greater amounts of mandibular recession. However, no clear evidence exists to confirm that orthognathic surgery is a causative factor for postoperative sleep breathing disorders in patients with mandibular prognathism. The wider upper airway in patients with class III skeletal might be the reason for the rare occurrence of OSA after surgery. In addition, obesity and advanced age may lead to sleep apnea after orthognathic surgery. Obese patients should be advised to lose weight preoperatively.

Association between periodontitis and temporomandibular joint disorders.

BACKGROUND: Periodontitis (PD) may affect temporomandibular joint disorders (TMD) and TMD may influence PD in previous observational studies. Nevertheless, these studies were prone to confounders and reverse causation, leading to incorrect conclusions about causality and direction of association. This research investigates the associations between PD and TMD employing bidirectional two-sample Mendelian randomization (MR) analysis. METHODS: Single-nucleotide polymorphisms (SNPs) related to PD (p < 5 × 10-6) were selected from a genome-wide association study (GWAS) from the Gene-Lifestyle Interaction in the Dental Endpoints (GLIDE) consortium, and related these to SNPs from FinnGen and UK Biobank (UKB) consortia, and vice versa. We implemented the standard inverse variance weighted (IVW), weighted median (WM), MR-Egger regression, and MR-PRESSO methods to estimate the potential causality between PD and TMD. Sensitive tests were conducted using robust MR methods. Results from FinnGen and UKB were combined using the fixed model. RESULTS: PD did not appear to causally affect TMD. Additionally, the reverse MR analysis did not reveal a significant causal effect of TMD on PD. The results of other MR methods were similar to those of the IVW method. Sensitivity analyses addressed no potential pleiotropy in MR estimations. Results from the meta-analysis were consistent with the above-mentioned consequences. CONCLUSION: This research does not support a causal relationship between PD and TMD. PD does not appear to worsen TMD directly, and vice versa.

Comparative study of biomechanical effects between two types of 2 × 4 techniques employing a rocking-chair archwire: a three-dimensional finite element analysis.

OBJECTIVES: After bonding brackets to the first deciduous molar in a 2 × 4 technique, a three-dimensional finite element analysis (3D FEA) is used to demonstrate the biomechanical changes in an orthodontic system. This study aims to opt for the appropriate type of orthodontic technology by analyzing and comparing the mechanical systems produced by two types of 2 × 4 techniques employing rocking-chair archwires. MATERIALS AND METHODS: Herein, the maxilla and maxillary dentition are modeled by cone beam computed tomography (CBCT) and 3D FEA. Common clinically used 0.016-inch round archwires (material: titanium-molybdenum alloy and stainless-steel) and 0.018-inch round archwires (material: titanium-molybdenum alloy and stainless-steel) are bent into the shape of a rocking chair with a depth of 3 mm. The forces and moments applied to the brackets are transferred to the dentition to evaluate the biomechanical effects of the 2 × 4 technique after the bracket is bonded to the first deciduous molar. RESULTS: For the central incisor, the teeth-moving distance in all three directions increases with bracket bonding to the first deciduous molar applying the 0.016-inch rocking-chair archwire. For the lateral incisor, the tooth root moves toward the gingival side when using 0.016-inch and 0.018-inch archwires. Moreover, for the same archwire size, the lateral incisors move toward the gingival side by bonding the bracket to the first deciduous molar. After bonding a bracket to the first deciduous molar, using rocking-chair archwires of 0.016 inch or 0.018 inch, the buccal movement distance of the first molar crown increases in the X-axis direction. In the Y-axis and Z-axis directions, the modified 2 × 4 technique significantly increases the effect of backward-tipping compared with the traditional 2 × 4 technique. CONCLUSIONS: In clinical practice, the modified 2 × 4 technique can be used to increase the movement distance of anterior teeth to a certain extent and accelerate the orthodontic teeth movement. Moreover, the modified 2 × 4 technique is better in anchorage conservation of the first molar than the traditional technique. CLINICAL RELEVANCE: Although the traditional 2 × 4 technique is widely used in early orthodontic treatment, we found mucosal damage and abnormal archwire deformation might affect orthodontic treatment time and effect. The modified 2 × 4 technique is a novel approach that avoids these drawbacks and improves orthodontic treatment efficiency.

Research progress on the role and mechanism of miR-671 in bone metabolism and bone-related diseases.

Bone metabolism consists of bone formation and resorption and maintains a dynamic balance in vivo. When bone homeostasis is broken, it can manifest as osteoarthritis (OA), rheumatoid arthritis (RA), osteosarcoma (OS), etc. MiR-671, an important class of non-coding nucleotide sequences in vivo, is regulated by lncRNA and regulates bone metabolism balance by regulating downstream target proteins and activating various signaling pathways. Based on the structure and primary function of miR-671, this paper summarizes the effect and mechanism of miR-671 in bone-related inflammation and cancer diseases, and prospects the application possibility of miR-671, providing reference information for targeted therapy of bone-related disorders.

[Research progress on the effect of surface charge of biomaterials on bone formation].

With the continuous progress of materials science and biology, the significance of biomaterials with dual characteristics of materials science and biology is keeping on increasing. Nowadays, more and more biomaterials are being used in tissue engineering, pharmaceutical engineering and regenerative medicine. In repairing bone defects caused by trauma, tumor invasion, congenital malformation and other factors, a variety of biomaterials have emerged with different characteristics, such as surface charge, surface wettability, surface composition, immune regulation and so on, leading to significant differences in repair effects. This paper mainly discusses the influence of surface charge of biomaterials on bone formation and the methods of introducing surface charge, aiming to promote bone formation by changing the charge distribution on the surface of the biomaterials to serve the clinical treatment better.